ParkinsonCanadaV1, Main, Exploration, bibRecord, 003276

The role of the striatum and hippocampus in planning : A PET activation study in Parkinson's disease

Identifieur interne : 003276 ( Main/Exploration ); précédent : 003275; suivant : 003277

The role of the striatum and hippocampus in planning : A PET activation study in Parkinson's disease

Auteurs : Alain Dagher [Royaume-Uni, Canada] ; Adrian M. Owen [Royaume-Uni] ; Henning Boecker [Royaume-Uni] ; David J. Brooks [Royaume-Uni]

Source :

Brain [ 0006-8950 ] ; 2001.

RBID : Pascal:01-0274997

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Tomoscintigraphie, Positon, Corps strié, Hippocampe, Physiopathologie, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Corpus striatum, Emission tomography, Hippocampus, Human, Parkinson disease, Pathophysiology, Positron.

Abstract

Previous work has identified the prefrontal cortex (PFC) and striatum as participating in the planning and selection of movements. We compared the brain activation patterns during planning in Parkinson's disease patients and age-matched controls using H₂¹⁵O-PET and the Tower of London (TOL) task. In this study, our mildly affected Parkinson's disease group performed as well as the control group but showed a different pattern of neuronal activation. In the two groups, overlapping areas of the PFC were activated but, whereas the right caudate nucleus was activated in the control group, this was not evident in the Parkinson's disease patients. This suggests that normal normal frontal lobe activation can occur in Parkinson's disease despite abnormal processing within the basal ganglia. Moreover, right hippocampus activity was suppressed in the controls and enhanced in the Parkinson's disease patients. This could represent a shift to the declarative memory system in Parkinson's disease during performance of the TOL task, possibly resulting from insufficient working memory capacity within the frontostriatal system.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000C33
to stream PascalFrancis, to step Curation: 000090
to stream PascalFrancis, to step Checkpoint: 000A52
to stream Main, to step Merge: 003759
to stream Main, to step Curation: 003276

Le document en format XML

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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

The role of the striatum and hippocampus in planning : A PET activation study in Parkinson's disease

The role of the striatum and hippocampus in planning : A PET activation study in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri